Aeternis Where Science and Timeless Health Converge
Scroll Down
Aeternis is your gateway to a new era of healthier aging, exploring the latest breakthroughs in longevity science and natural wellness. Our mission is to empower individuals to age gracefully, with vitality and purpose. Through expert insights, scientific discoveries, and practical tips, Aeternis delves deep into the realms of senescence, anti-aging nutrition, rejuvenation, and cutting-edge therapies that redefine what it means to live a longer, healthier life. Join us as we uncover the secrets to eternal well-being and unlock your fullest potential, one step at a time.
Start AeternisingKnow more about the top nutrients that combat the signs of aging.
Fisetin, a plant-derived flavonol from the flavonoid polyphenol family, is a natural yellow pigment found in various fruits and vegetables. Its name comes from the German word "fisetholz," a reference to a traditional yellow dye. Like other polyphenols, fisetin helps protect plants from environmental stressors. It is present in small amounts in foods like strawberries, apples, persimmons, grapes, onions, and cucumbers. Research on fisetin has mainly focused on its potential to promote cellular health and support neuroprotective mechanisms, making it a promising compound for healthy aging.
Promoting Healthy Aging and Cellular Function Fisetin supports overall healthy aging by promoting cellular health and aiding in the removal of damaged cells. It plays a critical role in helping the body manage stressed or senescent cells, thus maintaining tissue homeostasis as we age. Fisetin also supports vital processes like autophagy and mitophagy, which help recycle damaged cell components, contributing to longevity and cellular resilience.
Supporting Brain Health and Cognitive Function Fisetin has been shown to support healthy brain aging by improving cognition, synaptic function, and stress markers, especially in aging models and studies with senescent mice. It helps maintain the brain’s antioxidant defenses and regulates key signaling pathways like Sirt1 and Nrf2, which are essential for brain health. Additionally, fisetin may enhance mitochondrial function and support autophagy, processes that are vital for preventing cognitive decline
Boosting Immune and Cellular SignalingFisetin also influences several cellular signaling pathways, such as PI3K/AKT, mTOR, AMPK, and NF-κB, all of which are involved in regulating cell growth, metabolism, and inflammation. These pathways play key roles in immune signaling and maintaining a balanced immune response. Fisetin's ability to influence these pathways makes it a valuable compound for supporting the immune system and cellular health as we age.
Complementary Ingredients Fisetin works synergistically with other compounds like luteolin, which also influences immune signaling and enhances the overall health benefits of fisetin.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Quercetin is a natural yellow pigment found in many plants, particularly in parts exposed to environmental stress, such as the outer layers. It was first discovered in oak trees, which is reflected in its name, derived from the Latin quercetum (oak forest). As a flavonol, quercetin is part of the polyphenol family, compounds that plants use to defend against threats like UV radiation and pests. This protective property extends to human health as well, where quercetin plays a role in various health benefits. Common sources include red onions, where it concentrates in the outer skins and root ends, and capers, which are one of the richest dietary sources of this powerful flavonol.
Healthy Aging Support
Quercetin is widely recognized for its role in promoting healthy aging. It strengthens antioxidant defenses, protecting cells from oxidative stress, and supports overall cellular health by managing cellular stress and promoting longevity.
Brain Health and Cognitive Function
Quercetin has been shown to support brain function, particularly in animal studies. It may enhance learning and memory, promote motor activity, and help manage behavioral responses to stress. Research also suggests quercetin supports critical brain functions like the production of brain-derived neurotrophic factor (BDNF) and the regulation of neurotransmitters such as serotonin, dopamine, and noradrenaline. Additionally, it influences key enzymes that regulate brain activity and signaling, contributing to neuroprotection and supporting brain insulin signaling, mitochondrial function, and antioxidant defenses.
Gut Health and Immunity
Quercetin supports a healthy gut microbiome, promoting a balanced composition of gut bacteria and enhancing communication between the gut and the immune system. This helps maintain overall gut health and immunity, which are essential for well-being.
Musculoskeletal and Joint Health
Quercetin also supports musculoskeletal health by promoting joint health and aiding in muscle recovery after exercise. Its anti-inflammatory properties help maintain joint function, making it beneficial for individuals with joint issues.
Cellular Signaling and Longevity
Quercetin influences several key cellular pathways involved in aging and longevity, such as PI3K/AKT, mTOR, AMPK, and SIRT1 signaling. It also supports processes like autophagy and mitophagy, which help remove damaged cells and maintain cellular function. Additionally, quercetin helps manage senescent cells, promoting healthy aging and improving cellular resilience.
Complementary Ingredients
Quercetin's effects can be enhanced when combined with other ingredients. For example, palmitoylethanolamide supports joint health, while glucosamine and chondroitin contribute to overall joint function. Quercetin also works well with Mangifera indica leaf extract to support physical performance and recovery.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Piperlongumine is an amide-alkaloid primarily found in the long pepper plant (Piper longum), a close relative of black pepper (Piper nigrum). While black pepper is widely recognized and used globally, long pepper has a rich history in traditional healing systems, particularly in India and Thailand. In Ayurvedic medicine, long pepper is considered a rasayana, meaning a rejuvenating substance. Together with black pepper and ginger, it forms the well-known spice combination called Trikatu, renowned for its health benefits.
The active compound, piperlongumine, is not found in black pepper but is one of the key components that give long pepper its distinctive heat and complexity. This unique compound has gained significant attention in scientific research for its potential in promoting healthy aging and brain function, as well as its role in managing cellular stress and senescence.
Brain Health and Cognitive Function
Piperlongumine has been shown to support brain function, particularly in aging populations. Studies have demonstrated its ability to enhance cognitive function and support hippocampal health in older mice. Additionally, piperlongumine promotes neuroprotection by supporting the function of neural mitochondria and improving cerebral endothelial progenitor cell function, which helps maintain brain health and cognitive performance.
Neuroprotection and Stress Response
This compound also influences immune signaling within the brain, helping to manage astrocyte and microglia activation—two cell types critical in maintaining neural health. By regulating these immune responses, piperlongumine supports the brain's ability to handle stress and counteract damage, thereby promoting long-term brain health.
Healthy Aging and Cellular Longevity
One of the most exciting areas of research around piperlongumine is its potential to promote healthy aging. It has been found to assist in the management of senescent cells—old or damaged cells that no longer function properly but are not removed by the body. By helping to clear these cells, piperlongumine supports cellular renewal and reduces the burden of senescent cells on the body, promoting longevity.
Autophagy and Cellular Stress Management
Piperlongumine plays a crucial role in supporting autophagy, the body's natural process of clearing out damaged or dysfunctional cellular components. This mechanism helps the body cope with stress and maintain cellular health. Piperlongumine also boosts stress resistance, enhancing the body's ability to withstand oxidative stress and other environmental challenges.
Cellular Signaling Pathways
Piperlongumine influences several important cellular signaling pathways, such as PI3K/AKT, mTOR, and NF-κB. These pathways are critical for regulating cellular growth, metabolism, and inflammation. By modulating these signaling pathways, piperlongumine helps maintain cellular balance, supports immune function, and protects against the damage that can lead to aging and disease.
Piperlongumine, derived from the long pepper plant, offers a wide range of health benefits, particularly for brain function and healthy aging. Its ability to manage senescent cells, support neuroprotection, and promote autophagy makes it a promising natural compound for those looking to enhance longevity and maintain cognitive health.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Notoginseng root (Panax notoginseng) and sweet chestnut rose fruit (Rosa roxburghii) are two powerful natural ingredients that have been used in Traditional Chinese Medicine (TCM) for centuries. Both plants are known for their rich bioactive compounds and have been widely studied for their health benefits. Notoginseng is packed with polysaccharides and saponins, particularly ginsenosides, with Ginsenoside Rg1 being one of the most abundant. On the other hand, Rosa roxburghii is revered for its high levels of vitamin C, superoxide dismutase (SOD), and flavonoids, giving it potent antioxidant properties. Together, these two ingredients offer a wide range of health benefits, from improving exercise performance to promoting healthy aging.
Boosts Exercise Performance and Recovery
Notoginseng root has long been associated with enhancing physical performance and supporting muscle recovery. It aids in improving skeletal muscle metabolism and counters oxidative stress caused by exercise. This helps reduce muscle fatigue and supports the removal of damaged, senescent cells in muscles, allowing for faster recovery and enhanced muscle regeneration.
Supports Brain Health
Both notoginseng and sweet chestnut rose have been shown to offer neuroprotective benefits. Notoginseng helps promote cognitive function, enhance synaptic plasticity, and protect brain cells from oxidative stress. It also supports neural autophagy, which helps in cleaning out damaged cells in the brain, and influences immune signaling in neural tissues, helping to manage inflammation and protect against neural aging. Rosa roxburghii, with its high antioxidant content, further supports brain health by neutralizing harmful free radicals.
Promotes Gut-Brain Health
The combination of these two powerful plants supports a healthy gut microbiome, which is essential for overall well-being and the gut-brain axis. A healthy microbiome not only improves digestion but also plays a critical role in regulating brain health and mood.
Enhances Cellular Health and Longevity
Notoginseng and sweet chestnut rose are both known for their ability to support healthy aging by promoting cellular repair mechanisms. Notoginseng, in particular, influences key cellular pathways such as PI3K/AKT, AMPK, and mTOR, which regulate metabolism and cell growth. It also supports autophagy, helping the body clear out damaged cells, and promotes mitochondrial function, which is crucial for energy production and longevity.
Antioxidant and Immune Support
Rosa roxburghii is a powerful antioxidant source due to its high vitamin C and SOD content. These antioxidants help reduce oxidative stress, which can cause cellular damage and accelerate aging. Both plants also support immune function by regulating immune signaling pathways, helping the body respond better to stress and inflammation.
Cellular Signaling and Anti-Aging Effects
Both notoginseng and Rosa roxburghii play important roles in regulating the body's cellular signaling pathways, including PI3K/AKT, AMPK, and mTOR. These pathways are vital for maintaining healthy cellular metabolism, supporting stress responses, and enhancing longevity. Additionally, these plants influence autophagy and senescent cell clearance, which helps maintain cellular function as we age.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
The olive tree, native to the Mediterranean, is known not only for its fruit but also for its leaves, which have been used in traditional medicine for centuries. While olive oil is a staple of Mediterranean cuisine and renowned for its health benefits, the leaves, fruits, and oils all contain bioactive compounds, particularly polyphenols. Two of the most studied polyphenols in olives are oleuropein and hydroxytyrosol. Oleuropein, found in higher concentrations in olive leaf extracts, and hydroxytyrosol, more abundant in the fruit, contribute to olive's wide-ranging health benefits, particularly for brain and cardiovascular function.
Supporting Brain Health
Olive leaf extract has been shown to help support healthy brain function. It may improve spatial working memory and increase brain ATP levels, which are vital for energy. The extract also offers neuroprotective benefits, helping to preserve brain structure and protect the blood-brain barrier (BBB) while reducing oxidative stress. By supporting autophagy and reducing inflammation, olive leaf extract helps maintain cognitive function and may slow the aging process in the brain.
Cardiovascular and Metabolic Health
One of the most well-known benefits of olive leaf extract is its ability to support cardiovascular health. It promotes healthy blood vessels and helps regulate insulin signaling, making it useful for maintaining glucose balance and supporting overall cardiometabolic health.
Promoting Healthy Aging
Olive leaf extract supports healthy aging by promoting cellular repair mechanisms, including autophagy and anti-senescence processes. These actions help manage damaged cells, which is crucial for longevity. The extract also influences important cellular pathways, including AMPK, mTOR, and NF-κB, all of which play roles in metabolism and aging.
Complementary Ingredients
Olive leaf extract works well with other natural ingredients, such as curcumin from turmeric, which enhances cellular health, and berberine, which supports metabolic balance.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Milk thistle (Silybum marianum) is a flowering plant with a long history of use, especially in regions of Europe and the Mediterranean. For over 2,000 years, it has been used as a natural liver tonic. Native to Europe, milk thistle can now be found growing in parts of North and South America as well. Its key active compound is silymarin, a powerful blend of flavonolignans, including silybins A and B (often referred to collectively as silibinin), as well as isosilybins, silychristin, and silydianin, with taxifolin as their precursor. Research has extensively explored milk thistle's benefits for liver health, while more recent studies highlight its potential to support brain health, skin health, detoxification, metabolic health, and healthy aging.
Liver Health Support
Milk thistle is best known for its ability to support liver function. It helps maintain liver structure, assists in detoxification, and bolsters the liver's antioxidant defenses, protecting against oxidative stress. Additionally, milk thistle influences liver immune signaling, helping the liver respond to inflammation and maintain overall health.
Brain Health and Cognitive Support
Studies suggest milk thistle also offers benefits for brain health, including supporting cognitive function and promoting neuroprotection. It helps counter oxidative stress and supports brain mitochondrial function, which is crucial for maintaining energy levels in brain cells. By influencing autophagy and neural immune signaling, milk thistle may help protect against age-related cognitive decline.
Healthy Aging and Longevity
Milk thistle's impact extends beyond the liver and brain. It promotes healthy aging by supporting cellular functions that manage stressed or senescent cells. By influencing key signaling pathways like SIRT1, AMPK, and mTOR, it helps regulate autophagy and maintain vascular health, contributing to overall longevity.
Complementary Ingredients
Milk thistle pairs well with other natural compounds for enhanced benefits. Curcumin, derived from turmeric, supports cellular health, while Berberis aristata can help promote metabolic health.
Disclaimer: These statements are based on scientific research but have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Soy, a legume native to East Asia, has been used for centuries to create various fermented foods like soy sauce, tofu, tempeh, and miso. It contains isoflavones, a type of bioflavonoid commonly found in legumes, nuts, and seeds. Soybeans, in particular, are rich in isoflavones, with genistein, daidzein, and glycitein being the most prominent. Notably, daidzein can be converted by gut bacteria into equol, a more bioavailable compound that plays a key role in soy's health benefits.
Promoting Healthy Aging
Soybean seed extract is recognized for its role in promoting longevity and supporting the body's ability to manage cellular stress. It contributes to anti-senescence mechanisms, helping to delay the cellular aging process. Additionally, it supports autophagy, the body's way of removing damaged cells, which is essential for maintaining overall cellular health.
Enhancing Skin Health
Soy is widely valued for its potential skin benefits. It may help reduce the visible signs of aging, such as fine lines and wrinkles, while supporting skin elasticity. Soy also plays a crucial role in maintaining the structure of the skin's extracellular matrix (ECM) by supporting fibroblast activity, collagen production, and the maintenance of elastic fibers and hyaluronic acid. This helps keep the skin firm and resilient.
Soybean extract may also influence enzymes that break down the ECM and support the vascular health of the skin, allowing it to adapt to environmental stress. It further promotes healthy DNA repair and antioxidant defenses, helping the skin combat oxidative stress, which can accelerate aging. Soybean extract is thought to influence key signaling pathways such as ERβ and Nrf2, which are vital for skin health, and may also reduce the formation of advanced glycation end products (AGEs), molecules that contribute to skin aging.
Additional Benefits
Beyond its skin and aging benefits, soybean extract has shown potential to support cognitive health and maintain a balanced gut microbiota. It influences various signaling pathways in the body, including NF-κB, AMPK, and SIRT1, which are all involved in cellular stress response and longevity.
Complementary Ingredients
Soy's benefits are enhanced by other natural compounds. For example, astaxanthin, lycopene, vitamin C, and vitamin E are often used alongside soy to promote overall skin health and protect against environmental damage.
Disclaimer: These statements are based on research and are not evaluated by regulatory bodies such as the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
Brain Health and Cognitive Support
Luteolin is known for its potential to enhance brain function and cognitive abilities, as evidenced by animal studies. It may also play a role in protecting brain cells, which could support long-term cognitive health. Research suggests luteolin helps regulate the activity of microglia and astrocytes—cells involved in the brain's immune response—and influences signaling pathways that manage neural immunity. Additionally, luteolin appears to support brain mitochondria, which are crucial for cellular energy, while also enhancing antioxidant defenses that help counter oxidative stress, a key factor in aging and cognitive decline.
Luteolin may also activate Nrf2, a pathway linked to reducing oxidative stress, and promote autophagy, the process by which cells clean out damaged components, thus supporting overall brain health. It has been shown to boost levels of brain-derived neurotrophic factor (BDNF), which is essential for neurogenesis, or the formation of new neurons, an important process in maintaining cognitive function as we age.
Promoting Healthy Aging and Longevity
Beyond its brain-related benefits, luteolin is recognized for its potential in supporting cellular processes that contribute to healthy aging and longevity. It encourages the removal of damaged cells through processes like autophagy and mitophagy, which help keep cells functioning optimally. By influencing immune signaling, luteolin supports the body's ability to manage stressors that could otherwise accelerate aging.
Regulating Key Cellular Pathways
Luteolin impacts several key signaling pathways that are essential for maintaining cellular health. These include the PI3K/AKT and mTOR pathways, both of which are involved in cell growth and metabolism. Additionally, luteolin activates the AMPK pathway, which plays a role in energy regulation, and Nrf2, which helps combat oxidative stress. It also influences the NF-κB signaling pathway, which is linked to inflammation, thus further promoting a balanced cellular environment.
Complementary Ingredients
Other natural compounds like quercetin and fisetin complement luteolin's effects by promoting the apoptosis (programmed death) of unhealthy cells. Fisetin, in particular, also plays a role in modulating immune responses, adding to the overall health benefits of luteolin.
Note: These insights are based on emerging research and are not evaluated by regulatory bodies like the FDA. They are not intended to diagnose, treat, or prevent any disease.
Curcumin is the bright yellow-orange pigment found in turmeric, a spice derived from the Curcuma longa rhizome, a member of the ginger family. Often referred to as the "golden spice," turmeric has been used for centuries in South Asian cuisine and Ayurvedic medicine. Known for its vibrant color and earthy flavor, turmeric is more than just a culinary ingredient—its active compound, curcumin, offers a wide range of health benefits.
Curcumin has been extensively studied for its numerous health-promoting properties. It plays a significant role in supporting cognitive function, promoting joint and cardiovascular health, enhancing exercise recovery, and contributing to healthy aging. Let's explore some of the key benefits associated with curcumin.
1. Brain Health and Cognitive Support
Curcumin is renowned for its ability to support brain function, particularly in aging individuals. Research shows that it can enhance working memory, attention, and overall cognitive performance. It also promotes neuroprotection by reducing oxidative stress, supporting healthy brain signaling, and even influencing the growth and maintenance of dendritic spines, which are critical for memory and learning.
2. Exercise Recovery and Physical Performance
Curcumin has been found to aid in exercise recovery by reducing inflammation and oxidative stress that occurs after intense physical activity. Athletes and fitness enthusiasts can benefit from curcumin's ability to promote faster muscle recovery and improve overall endurance. This makes it an excellent addition to a post-workout routine, helping to support both physical performance and resilience.
3. Eye Health and Vision Protection
In addition to its cognitive and physical benefits, curcumin supports eye health. Studies show that it helps maintain healthy retinal function and protects against damage from blue light exposure, which is increasingly important in today's digital world. Curcumin's antioxidant properties are also essential in defending the eyes from oxidative stress, which can lead to long-term vision problems.
4. Gut Health and Microbiome Balance
Curcumin plays a role in promoting a healthy gut by supporting the balance of beneficial gut bacteria. It aids in improving gut barrier function and influences gut microbiota metabolism, contributing to better digestive health and overall well-being. This is particularly valuable as gut health is closely linked to immune function, mood regulation, and even cognitive performance.
5. Supports Healthy Aging and Longevity
As an anti-aging powerhouse, curcumin helps manage the body's response to cellular stress and senescence—the aging of cells. It promotes the removal of damaged cells and supports autophagy, the process by which the body cleans out harmful debris from its cells. This action helps maintain cellular health, which is vital for longevity and aging gracefully. Additionally, curcumin influences several key cellular pathways like PI3K/AKT and NF-κB signaling, which are involved in inflammation and cellular repair.
6. Mood and Emotional Well-Being
Curcumin also plays a role in mood regulation. It has been shown to promote a calm and positive mood by supporting the brain's natural chemical balance. Its ability to influence serotonin and dopamine levels can help individuals maintain emotional well-being and mental clarity.
Curcumin, the golden compound from turmeric, is much more than a vibrant spice—it offers extensive health benefits, from supporting brain function and exercise recovery to promoting gut health and longevity. Whether you're looking to maintain cognitive clarity, protect your vision, or support healthy aging, curcumin is a valuable natural ingredient that can be easily incorporated into a healthy lifestyle.
Disclaimer: These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease